This Practice Note analyzes the key issues that parties should consider when they draft, issue, and serve subpoenas to obtain evidence in federal civil litigation under Rule 45 of the Federal Rules of Civil Procedure (FRCP). Specifically, this Note addresses the situations in which a party should use a subpoena, what information a party must include in a subpoena, who may issue a subpoena, how to serve a subpoena, how to calculate the fee to pay to the subpoenaed witness, and how to provide notice of the subpoena to the other parties.