A Practice Note outlining the key issues to consider when responding to a subpoena in federal civil litigation under Federal Rule of Civil Procedure (FRCP 45). Specifically, this Note covers how to comply with a subpoena, the various ways one can object to (or move to quash) a subpoena, and how to appeal a decision compelling or denying the discovery a subpoena seeks. It also explains the consequences of failing to timely object to (or comply with) an otherwise valid subpoena.