A Practice Note addressing motions to transfer venue in federal civil litigation under both 28 U.S.C. § 1406(a) (when venue is improper) and 28 U.S.C. § 1404(a) (when venue is proper but transfer to another venue is appropriate for convenience). This Note discusses key considerations surrounding transfer, including reasons to seek transfer, the factors courts consider in deciding transfer motions, sanctions for frivolous transfer motions, and appellate review of orders on transfer motions.